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16\times 2^{-8}-4\times \left(2^{-2}\right)^{-3}+2\times \left(2^{-2}\right)^{-1}-5\times \left(2^{-2}\right)^{2}
To raise a power to another power, multiply the exponents. Multiply -2 and 4 to get -8.
16\times 2^{-8}-4\times 2^{6}+2\times \left(2^{-2}\right)^{-1}-5\times \left(2^{-2}\right)^{2}
To raise a power to another power, multiply the exponents. Multiply -2 and -3 to get 6.
16\times 2^{-8}-4\times 2^{6}+2\times 2^{2}-5\times \left(2^{-2}\right)^{2}
To raise a power to another power, multiply the exponents. Multiply -2 and -1 to get 2.
16\times 2^{-8}-4\times 2^{6}+2^{3}-5\times \left(2^{-2}\right)^{2}
To multiply powers of the same base, add their exponents. Add 1 and 2 to get 3.
16\times 2^{-8}-4\times 2^{6}+2^{3}-5\times 2^{-4}
To raise a power to another power, multiply the exponents. Multiply -2 and 2 to get -4.
16\times \frac{1}{256}-4\times 2^{6}+2^{3}-5\times 2^{-4}
Calculate 2 to the power of -8 and get \frac{1}{256}.
\frac{1}{16}-4\times 2^{6}+2^{3}-5\times 2^{-4}
Multiply 16 and \frac{1}{256} to get \frac{1}{16}.
\frac{1}{16}-4\times 64+2^{3}-5\times 2^{-4}
Calculate 2 to the power of 6 and get 64.
\frac{1}{16}-256+2^{3}-5\times 2^{-4}
Multiply 4 and 64 to get 256.
-\frac{4095}{16}+2^{3}-5\times 2^{-4}
Subtract 256 from \frac{1}{16} to get -\frac{4095}{16}.
-\frac{4095}{16}+8-5\times 2^{-4}
Calculate 2 to the power of 3 and get 8.
-\frac{3967}{16}-5\times 2^{-4}
Add -\frac{4095}{16} and 8 to get -\frac{3967}{16}.
-\frac{3967}{16}-5\times \frac{1}{16}
Calculate 2 to the power of -4 and get \frac{1}{16}.
-\frac{3967}{16}-\frac{5}{16}
Multiply 5 and \frac{1}{16} to get \frac{5}{16}.
-\frac{993}{4}
Subtract \frac{5}{16} from -\frac{3967}{16} to get -\frac{993}{4}.