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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-91x^{3})
Combine 125x^{3} and -216x^{3} to get -91x^{3}.
3\left(-91\right)x^{3-1}
The derivative of ax^{n} is nax^{n-1}.
-273x^{3-1}
Multiply 3 times -91.
-273x^{2}
Subtract 1 from 3.
-91x^{3}
Combine 125x^{3} and -216x^{3} to get -91x^{3}.