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Differentiate w.r.t. x
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10x^{1-1}+4x^{4-1}+3\times 4x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
10x^{0}+4x^{4-1}+3\times 4x^{3-1}
Subtract 1 from 1.
10x^{0}+4x^{3}+3\times 4x^{3-1}
Subtract 1 from 4.
10x^{0}+4x^{3}+12x^{3-1}
Multiply 4 times 1.
10x^{0}+4x^{3}+12x^{2}
Subtract 1 from 3.
10\times 1+4x^{3}+12x^{2}
For any term t except 0, t^{0}=1.
10+4x^{3}+12x^{2}
For any term t, t\times 1=t and 1t=t.