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Differentiate w.r.t. E
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\frac{35}{65000}E^{-12}
Expand \frac{0.35}{650} by multiplying both numerator and the denominator by 100.
\frac{7}{13000}E^{-12}
Reduce the fraction \frac{35}{65000} to lowest terms by extracting and canceling out 5.
-12\times \frac{7}{13000}E^{-12-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{21}{3250}E^{-12-1}
Multiply -12 times \frac{7}{13000}.
-\frac{21}{3250}E^{-13}
Subtract 1 from -12.