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\frac{1}{4}-\frac{4}{81}
Convert decimal number 0.25 to fraction \frac{25}{100}. Reduce the fraction \frac{25}{100} to lowest terms by extracting and canceling out 25.
\frac{81}{324}-\frac{16}{324}
Least common multiple of 4 and 81 is 324. Convert \frac{1}{4} and \frac{4}{81} to fractions with denominator 324.
\frac{81-16}{324}
Since \frac{81}{324} and \frac{16}{324} have the same denominator, subtract them by subtracting their numerators.
\frac{65}{324}
Subtract 16 from 81 to get 65.