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-x^{4}+5x^{2}-4=0
Swap sides so that all variable terms are on the left hand side.
-t^{2}+5t-4=0
Substitute t for x^{2}.
t=\frac{-5±\sqrt{5^{2}-4\left(-1\right)\left(-4\right)}}{-2}
All equations of the form ax^{2}+bx+c=0 can be solved using the quadratic formula: \frac{-b±\sqrt{b^{2}-4ac}}{2a}. Substitute -1 for a, 5 for b, and -4 for c in the quadratic formula.
t=\frac{-5±3}{-2}
Do the calculations.
t=1 t=4
Solve the equation t=\frac{-5±3}{-2} when ± is plus and when ± is minus.
x=1 x=-1 x=2 x=-2
Since x=t^{2}, the solutions are obtained by evaluating x=±\sqrt{t} for each t.