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Differentiate w.r.t. x
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5\left(-9\right)x^{5-1}+3\left(-8\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-45x^{5-1}+3\left(-8\right)x^{3-1}
Multiply 5 times -9.
-45x^{4}+3\left(-8\right)x^{3-1}
Subtract 1 from 5.
-45x^{4}-24x^{3-1}
Multiply 3 times -8.
-45x^{4}-24x^{2}
Subtract 1 from 3.