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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-4x^{3})
Multiply -2 and 2 to get -4.
3\left(-4\right)x^{3-1}
The derivative of ax^{n} is nax^{n-1}.
-12x^{3-1}
Multiply 3 times -4.
-12x^{2}
Subtract 1 from 3.
-4x^{3}
Multiply -2 and 2 to get -4.