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Differentiate w.r.t. n
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5\left(-1\right)n^{5-1}+3\left(-9\right)n^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-5n^{5-1}+3\left(-9\right)n^{3-1}
Multiply 5 times -1.
-5n^{4}+3\left(-9\right)n^{3-1}
Subtract 1 from 5.
-5n^{4}-27n^{3-1}
Multiply 3 times -9.
-5n^{4}-27n^{2}
Subtract 1 from 3.