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Differentiate w.r.t. c_190
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\frac{\left(-c_{190}\right)\times 12}{19}
Divide -c_{190} by \frac{19}{12} by multiplying -c_{190} by the reciprocal of \frac{19}{12}.
\frac{-12c_{190}}{19}
Multiply -1 and 12 to get -12.