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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(-2a^{16})
Combine -a^{16} and -a^{16} to get -2a^{16}.
16\left(-2\right)a^{16-1}
The derivative of ax^{n} is nax^{n-1}.
-32a^{16-1}
Multiply 16 times -2.
-32a^{15}
Subtract 1 from 16.
-2a^{16}
Combine -a^{16} and -a^{16} to get -2a^{16}.