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Differentiate w.r.t. x
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4\left(-9\right)x^{4-1}+2\left(-16y_{3}\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-36x^{4-1}+2\left(-16y_{3}\right)x^{2-1}
Multiply 4 times -9.
-36x^{3}+2\left(-16y_{3}\right)x^{2-1}
Subtract 1 from 4.
-36x^{3}+\left(-32y_{3}\right)x^{2-1}
Multiply 2 times -16y_{3}.
-36x^{3}+\left(-32y_{3}\right)x^{1}
Subtract 1 from 2.
-36x^{3}+\left(-32y_{3}\right)x
For any term t, t^{1}=t.