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-81+\frac{8+1}{4}+\frac{\frac{1}{9}}{-16}
Multiply 2 and 4 to get 8.
-81+\frac{9}{4}+\frac{\frac{1}{9}}{-16}
Add 8 and 1 to get 9.
-\frac{324}{4}+\frac{9}{4}+\frac{\frac{1}{9}}{-16}
Convert -81 to fraction -\frac{324}{4}.
\frac{-324+9}{4}+\frac{\frac{1}{9}}{-16}
Since -\frac{324}{4} and \frac{9}{4} have the same denominator, add them by adding their numerators.
-\frac{315}{4}+\frac{\frac{1}{9}}{-16}
Add -324 and 9 to get -315.
-\frac{315}{4}+\frac{1}{9\left(-16\right)}
Express \frac{\frac{1}{9}}{-16} as a single fraction.
-\frac{315}{4}+\frac{1}{-144}
Multiply 9 and -16 to get -144.
-\frac{315}{4}-\frac{1}{144}
Fraction \frac{1}{-144} can be rewritten as -\frac{1}{144} by extracting the negative sign.
-\frac{11340}{144}-\frac{1}{144}
Least common multiple of 4 and 144 is 144. Convert -\frac{315}{4} and \frac{1}{144} to fractions with denominator 144.
\frac{-11340-1}{144}
Since -\frac{11340}{144} and \frac{1}{144} have the same denominator, subtract them by subtracting their numerators.
-\frac{11341}{144}
Subtract 1 from -11340 to get -11341.