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Differentiate w.r.t. x
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4\left(-3\right)x^{4-1}+3x^{3-1}+2\left(-5\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-12x^{4-1}+3x^{3-1}+2\left(-5\right)x^{2-1}
Multiply 4 times -3.
-12x^{3}+3x^{3-1}+2\left(-5\right)x^{2-1}
Subtract 1 from 4.
-12x^{3}+3x^{2}+2\left(-5\right)x^{2-1}
Subtract 1 from 3.
-12x^{3}+3x^{2}-10x^{2-1}
Multiply 3 times 1.
-12x^{3}+3x^{2}-10x^{1}
Subtract 1 from 2.
-12x^{3}+3x^{2}-10x
For any term t, t^{1}=t.