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-3x^{2}\times 4^{2}\left(x^{3}\right)^{2}y^{2}
Expand \left(4x^{3}y\right)^{2}.
-3x^{2}\times 4^{2}x^{6}y^{2}
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
-3x^{2}\times 16x^{6}y^{2}
Calculate 4 to the power of 2 and get 16.
-48x^{2}x^{6}y^{2}
Multiply -3 and 16 to get -48.
-48x^{8}y^{2}
To multiply powers of the same base, add their exponents. Add 2 and 6 to get 8.
-3x^{2}\times 4^{2}\left(x^{3}\right)^{2}y^{2}
Expand \left(4x^{3}y\right)^{2}.
-3x^{2}\times 4^{2}x^{6}y^{2}
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
-3x^{2}\times 16x^{6}y^{2}
Calculate 4 to the power of 2 and get 16.
-48x^{2}x^{6}y^{2}
Multiply -3 and 16 to get -48.
-48x^{8}y^{2}
To multiply powers of the same base, add their exponents. Add 2 and 6 to get 8.