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-9+\left(-0.25\right)^{100}\times 4^{100}+\left(\frac{1}{2}-\frac{1}{3}\right)\times \left(\frac{1}{6}\right)^{-2}
Calculate 3 to the power of 2 and get 9.
-9+0.00000000000000000000000000000000000000000000000000000000000062230152778611417071440640537801242405902521687211671331011166147896988340353834411839448231257136169569665895551224821247160434722900390625\times 4^{100}+\left(\frac{1}{2}-\frac{1}{3}\right)\times \left(\frac{1}{6}\right)^{-2}
Calculate -0.25 to the power of 100 and get 0.00000000000000000000000000000000000000000000000000000000000062230152778611417071440640537801242405902521687211671331011166147896988340353834411839448231257136169569665895551224821247160434722900390625.
-9+0.00000000000000000000000000000000000000000000000000000000000062230152778611417071440640537801242405902521687211671331011166147896988340353834411839448231257136169569665895551224821247160434722900390625\times 1606938044258990275541962092341162602522202993782792835301376+\left(\frac{1}{2}-\frac{1}{3}\right)\times \left(\frac{1}{6}\right)^{-2}
Calculate 4 to the power of 100 and get 1606938044258990275541962092341162602522202993782792835301376.
-9+1+\left(\frac{1}{2}-\frac{1}{3}\right)\times \left(\frac{1}{6}\right)^{-2}
Multiply 0.00000000000000000000000000000000000000000000000000000000000062230152778611417071440640537801242405902521687211671331011166147896988340353834411839448231257136169569665895551224821247160434722900390625 and 1606938044258990275541962092341162602522202993782792835301376 to get 1.
-8+\left(\frac{1}{2}-\frac{1}{3}\right)\times \left(\frac{1}{6}\right)^{-2}
Add -9 and 1 to get -8.
-8+\frac{1}{6}\times \left(\frac{1}{6}\right)^{-2}
Subtract \frac{1}{3} from \frac{1}{2} to get \frac{1}{6}.
-8+\frac{1}{6}\times 36
Calculate \frac{1}{6} to the power of -2 and get 36.
-8+6
Multiply \frac{1}{6} and 36 to get 6.
-2
Add -8 and 6 to get -2.