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Differentiate w.r.t. x
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7\left(-27\right)x^{7-1}-50x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-189x^{7-1}-50x^{1-1}
Multiply 7 times -27.
-189x^{6}-50x^{1-1}
Subtract 1 from 7.
-189x^{6}-50x^{0}
Subtract 1 from 1.
-189x^{6}-50
For any term t except 0, t^{0}=1.