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-2\left(16x^{2}-8xy+y^{2}\right)+5\left(-2x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(4x-y\right)^{2}.
-32x^{2}+16xy-2y^{2}+5\left(-2x+y\right)^{2}
Use the distributive property to multiply -2 by 16x^{2}-8xy+y^{2}.
-32x^{2}+16xy-2y^{2}+5\left(4x^{2}-4xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-2x+y\right)^{2}.
-32x^{2}+16xy-2y^{2}+20x^{2}-20xy+5y^{2}
Use the distributive property to multiply 5 by 4x^{2}-4xy+y^{2}.
-12x^{2}+16xy-2y^{2}-20xy+5y^{2}
Combine -32x^{2} and 20x^{2} to get -12x^{2}.
-12x^{2}-4xy-2y^{2}+5y^{2}
Combine 16xy and -20xy to get -4xy.
-12x^{2}-4xy+3y^{2}
Combine -2y^{2} and 5y^{2} to get 3y^{2}.
-2\left(16x^{2}-8xy+y^{2}\right)+5\left(-2x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(4x-y\right)^{2}.
-32x^{2}+16xy-2y^{2}+5\left(-2x+y\right)^{2}
Use the distributive property to multiply -2 by 16x^{2}-8xy+y^{2}.
-32x^{2}+16xy-2y^{2}+5\left(4x^{2}-4xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-2x+y\right)^{2}.
-32x^{2}+16xy-2y^{2}+20x^{2}-20xy+5y^{2}
Use the distributive property to multiply 5 by 4x^{2}-4xy+y^{2}.
-12x^{2}+16xy-2y^{2}-20xy+5y^{2}
Combine -32x^{2} and 20x^{2} to get -12x^{2}.
-12x^{2}-4xy-2y^{2}+5y^{2}
Combine 16xy and -20xy to get -4xy.
-12x^{2}-4xy+3y^{2}
Combine -2y^{2} and 5y^{2} to get 3y^{2}.