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Differentiate w.r.t. x
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-21x^{1-1}+2\times 18x^{2-1}+3\left(-8\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-21x^{0}+2\times 18x^{2-1}+3\left(-8\right)x^{3-1}
Subtract 1 from 1.
-21x^{0}+36x^{2-1}+3\left(-8\right)x^{3-1}
Multiply 2 times 18.
-21x^{0}+36x^{1}+3\left(-8\right)x^{3-1}
Subtract 1 from 2.
-21x^{0}+36x^{1}-24x^{3-1}
Multiply 2 times 18.
-21x^{0}+36x^{1}-24x^{2}
Subtract 1 from 3.
-21x^{0}+36x-24x^{2}
For any term t, t^{1}=t.
-21+36x-24x^{2}
For any term t except 0, t^{0}=1.
-12-21x+18x^{2}-8x^{3}
Multiply 2 and 4 to get 8.