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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(-a^{6})
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
6\left(-1\right)a^{6-1}
The derivative of ax^{n} is nax^{n-1}.
-6a^{6-1}
Multiply 6 times -1.
-6a^{5}
Subtract 1 from 6.