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-\left(10p-1\times 5q\right)^{2}-\left(1-5p-2-5q\right)^{2}
Multiply 2 and 5 to get 10.
-\left(10p-5q\right)^{2}-\left(1-5p-2-5q\right)^{2}
Multiply 1 and 5 to get 5.
-\left(100p^{2}-100pq+25q^{2}\right)-\left(1-5p-2-5q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(10p-5q\right)^{2}.
-100p^{2}+100pq-25q^{2}-\left(1-5p-2-5q\right)^{2}
To find the opposite of 100p^{2}-100pq+25q^{2}, find the opposite of each term.
-100p^{2}+100pq-25q^{2}-\left(-1-5p-5q\right)^{2}
Subtract 2 from 1 to get -1.
-100p^{2}+100pq-25q^{2}-\left(25p^{2}+50pq+10p+25q^{2}+10q+1\right)
Square -1-5p-5q.
-100p^{2}+100pq-25q^{2}-25p^{2}-50pq-10p-25q^{2}-10q-1
To find the opposite of 25p^{2}+50pq+10p+25q^{2}+10q+1, find the opposite of each term.
-125p^{2}+100pq-25q^{2}-50pq-10p-25q^{2}-10q-1
Combine -100p^{2} and -25p^{2} to get -125p^{2}.
-125p^{2}+50pq-25q^{2}-10p-25q^{2}-10q-1
Combine 100pq and -50pq to get 50pq.
-125p^{2}+50pq-50q^{2}-10p-10q-1
Combine -25q^{2} and -25q^{2} to get -50q^{2}.
-\left(10p-1\times 5q\right)^{2}-\left(1-5p-2-5q\right)^{2}
Multiply 2 and 5 to get 10.
-\left(10p-5q\right)^{2}-\left(1-5p-2-5q\right)^{2}
Multiply 1 and 5 to get 5.
-\left(100p^{2}-100pq+25q^{2}\right)-\left(1-5p-2-5q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(10p-5q\right)^{2}.
-100p^{2}+100pq-25q^{2}-\left(1-5p-2-5q\right)^{2}
To find the opposite of 100p^{2}-100pq+25q^{2}, find the opposite of each term.
-100p^{2}+100pq-25q^{2}-\left(-1-5p-5q\right)^{2}
Subtract 2 from 1 to get -1.
-100p^{2}+100pq-25q^{2}-\left(25p^{2}+50pq+10p+25q^{2}+10q+1\right)
Square -1-5p-5q.
-100p^{2}+100pq-25q^{2}-25p^{2}-50pq-10p-25q^{2}-10q-1
To find the opposite of 25p^{2}+50pq+10p+25q^{2}+10q+1, find the opposite of each term.
-125p^{2}+100pq-25q^{2}-50pq-10p-25q^{2}-10q-1
Combine -100p^{2} and -25p^{2} to get -125p^{2}.
-125p^{2}+50pq-25q^{2}-10p-25q^{2}-10q-1
Combine 100pq and -50pq to get 50pq.
-125p^{2}+50pq-50q^{2}-10p-10q-1
Combine -25q^{2} and -25q^{2} to get -50q^{2}.