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\frac{-5}{\left(\frac{1}{4}\right)^{4}}
Calculate the square root of 25 and get 5.
\frac{-5}{\frac{1}{256}}
Calculate \frac{1}{4} to the power of 4 and get \frac{1}{256}.
-5\times 256
Divide -5 by \frac{1}{256} by multiplying -5 by the reciprocal of \frac{1}{256}.
-1280
Multiply -5 and 256 to get -1280.