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-\frac{4}{3}-\frac{15}{88}
Reduce the fraction \frac{8}{6} to lowest terms by extracting and canceling out 2.
-\frac{352}{264}-\frac{45}{264}
Least common multiple of 3 and 88 is 264. Convert -\frac{4}{3} and \frac{15}{88} to fractions with denominator 264.
\frac{-352-45}{264}
Since -\frac{352}{264} and \frac{45}{264} have the same denominator, subtract them by subtracting their numerators.
-\frac{397}{264}
Subtract 45 from -352 to get -397.