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Evaluate
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Differentiate w.r.t. x_0
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\frac{-2x_{0}}{2y_{0}}
Multiply -\frac{1}{2} times \frac{2x_{0}}{y_{0}} by multiplying numerator times numerator and denominator times denominator.
\frac{-x_{0}}{y_{0}}
Cancel out 2 in both numerator and denominator.