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x^{2}-4xy+xz+4yx-16y^{2}+4yz-zx+4zy-z^{2}
Apply the distributive property by multiplying each term of x+4y-z by each term of x-4y+z.
x^{2}+xz-16y^{2}+4yz-zx+4zy-z^{2}
Combine -4xy and 4yx to get 0.
x^{2}-16y^{2}+4yz+4zy-z^{2}
Combine xz and -zx to get 0.
x^{2}-16y^{2}+8yz-z^{2}
Combine 4yz and 4zy to get 8yz.
x^{2}-4xy+xz+4yx-16y^{2}+4yz-zx+4zy-z^{2}
Apply the distributive property by multiplying each term of x+4y-z by each term of x-4y+z.
x^{2}+xz-16y^{2}+4yz-zx+4zy-z^{2}
Combine -4xy and 4yx to get 0.
x^{2}-16y^{2}+4yz+4zy-z^{2}
Combine xz and -zx to get 0.
x^{2}-16y^{2}+8yz-z^{2}
Combine 4yz and 4zy to get 8yz.