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Differentiate w.r.t. x
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5\times 3x^{5-1}+3\left(-3\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
15x^{5-1}+3\left(-3\right)x^{3-1}
Multiply 5 times 3.
15x^{4}+3\left(-3\right)x^{3-1}
Subtract 1 from 5.
15x^{4}-9x^{3-1}
Multiply 3 times -3.
15x^{4}-9x^{2}
Subtract 1 from 3.