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x^{2}+4x-6x-24+\left(4x-1\right)\left(x-16\right)
Apply the distributive property by multiplying each term of x-6 by each term of x+4.
x^{2}-2x-24+\left(4x-1\right)\left(x-16\right)
Combine 4x and -6x to get -2x.
x^{2}-2x-24+4x^{2}-64x-x+16
Apply the distributive property by multiplying each term of 4x-1 by each term of x-16.
x^{2}-2x-24+4x^{2}-65x+16
Combine -64x and -x to get -65x.
5x^{2}-2x-24-65x+16
Combine x^{2} and 4x^{2} to get 5x^{2}.
5x^{2}-67x-24+16
Combine -2x and -65x to get -67x.
5x^{2}-67x-8
Add -24 and 16 to get -8.
x^{2}+4x-6x-24+\left(4x-1\right)\left(x-16\right)
Apply the distributive property by multiplying each term of x-6 by each term of x+4.
x^{2}-2x-24+\left(4x-1\right)\left(x-16\right)
Combine 4x and -6x to get -2x.
x^{2}-2x-24+4x^{2}-64x-x+16
Apply the distributive property by multiplying each term of 4x-1 by each term of x-16.
x^{2}-2x-24+4x^{2}-65x+16
Combine -64x and -x to get -65x.
5x^{2}-2x-24-65x+16
Combine x^{2} and 4x^{2} to get 5x^{2}.
5x^{2}-67x-24+16
Combine -2x and -65x to get -67x.
5x^{2}-67x-8
Add -24 and 16 to get -8.