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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(x^{4}\left(-x^{3}\right)+5x^{2}yy^{2}-4x^{2}\left(-x^{5}\right)-2x\left(-x^{4}\right)+4-\left(-x^{2}\right)\left(-x^{3}\right))
Multiply x and x to get x^{2}.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{4}\left(-x^{3}\right)+5x^{2}y^{3}-4x^{2}\left(-x^{5}\right)-2x\left(-x^{4}\right)+4-\left(-x^{2}\right)\left(-x^{3}\right))
To multiply powers of the same base, add their exponents. Add 1 and 2 to get 3.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{4}\left(-x^{3}\right)+5x^{2}y^{3}+4x^{2}x^{5}-2x\left(-x^{4}\right)+4-\left(-x^{2}\right)\left(-x^{3}\right))
Multiply -4 and -1 to get 4.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{4}\left(-x^{3}\right)+5x^{2}y^{3}+4x^{7}-2x\left(-x^{4}\right)+4-\left(-x^{2}\right)\left(-x^{3}\right))
To multiply powers of the same base, add their exponents. Add 2 and 5 to get 7.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{7}\left(-1\right)+5x^{2}y^{3}+4x^{7}-2x\left(-1\right)x^{4}+4-\left(-x^{2}\left(-1\right)x^{3}\right))
To multiply powers of the same base, add their exponents. Add 4 and 3 to get 7.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}-2x\left(-1\right)x^{4}+4-\left(-x^{2}\left(-1\right)x^{3}\right))
Combine x^{7}\left(-1\right) and 4x^{7} to get 3x^{7}.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}-2x^{5}\left(-1\right)+4-\left(-x^{2}\left(-1\right)x^{3}\right))
To multiply powers of the same base, add their exponents. Add 1 and 4 to get 5.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}+2x^{5}+4-\left(-x^{2}\left(-1\right)x^{3}\right))
Multiply -2 and -1 to get 2.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}+2x^{5}+4-\left(-x^{5}\left(-1\right)\right))
To multiply powers of the same base, add their exponents. Add 2 and 3 to get 5.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}+2x^{5}+4+x^{5}\left(-1\right))
Multiply -1 and -1 to get 1.
\frac{\mathrm{d}}{\mathrm{d}x}(3x^{7}+5x^{2}y^{3}+x^{5}+4)
Combine 2x^{5} and x^{5}\left(-1\right) to get x^{5}.
7\times 3x^{7-1}+2\times 5y^{3}x^{2-1}+5x^{5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
21x^{7-1}+2\times 5y^{3}x^{2-1}+5x^{5-1}
Multiply 7 times 3.
21x^{6}+2\times 5y^{3}x^{2-1}+5x^{5-1}
Subtract 1 from 7.
21x^{6}+10y^{3}x^{2-1}+5x^{5-1}
Multiply 2 times 5y^{3}.
21x^{6}+10y^{3}x^{1}+5x^{5-1}
Subtract 1 from 2.
21x^{6}+10y^{3}x^{1}+5x^{4}
Subtract 1 from 5.
21x^{6}+10y^{3}x+5x^{4}
For any term t, t^{1}=t.