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\left(x^{2}\right)^{2}-2x^{2}+1-18\left(x^{2}-1\right)+45=0
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x^{2}-1\right)^{2}.
x^{4}-2x^{2}+1-18\left(x^{2}-1\right)+45=0
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
x^{4}-2x^{2}+1-18x^{2}+18+45=0
Use the distributive property to multiply -18 by x^{2}-1.
x^{4}-20x^{2}+1+18+45=0
Combine -2x^{2} and -18x^{2} to get -20x^{2}.
x^{4}-20x^{2}+19+45=0
Add 1 and 18 to get 19.
x^{4}-20x^{2}+64=0
Add 19 and 45 to get 64.
t^{2}-20t+64=0
Substitute t for x^{2}.
t=\frac{-\left(-20\right)±\sqrt{\left(-20\right)^{2}-4\times 1\times 64}}{2}
All equations of the form ax^{2}+bx+c=0 can be solved using the quadratic formula: \frac{-b±\sqrt{b^{2}-4ac}}{2a}. Substitute 1 for a, -20 for b, and 64 for c in the quadratic formula.
t=\frac{20±12}{2}
Do the calculations.
t=16 t=4
Solve the equation t=\frac{20±12}{2} when ± is plus and when ± is minus.
x=4 x=-4 x=2 x=-2
Since x=t^{2}, the solutions are obtained by evaluating x=±\sqrt{t} for each t.