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\left(x^{2}\right)^{2}+4x^{2}x+4x^{2}-18\left(x^{2}+2x\right)+45
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x^{2}+2x\right)^{2}.
x^{4}+4x^{2}x+4x^{2}-18\left(x^{2}+2x\right)+45
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
x^{4}+4x^{3}+4x^{2}-18\left(x^{2}+2x\right)+45
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
x^{4}+4x^{3}+4x^{2}-18x^{2}-36x+45
Use the distributive property to multiply -18 by x^{2}+2x.
x^{4}+4x^{3}-14x^{2}-36x+45
Combine 4x^{2} and -18x^{2} to get -14x^{2}.
\left(x^{2}\right)^{2}+4x^{2}x+4x^{2}-18\left(x^{2}+2x\right)+45
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x^{2}+2x\right)^{2}.
x^{4}+4x^{2}x+4x^{2}-18\left(x^{2}+2x\right)+45
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
x^{4}+4x^{3}+4x^{2}-18\left(x^{2}+2x\right)+45
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
x^{4}+4x^{3}+4x^{2}-18x^{2}-36x+45
Use the distributive property to multiply -18 by x^{2}+2x.
x^{4}+4x^{3}-14x^{2}-36x+45
Combine 4x^{2} and -18x^{2} to get -14x^{2}.