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2x^{2}+5x+16x+40-\left(x+8\right)\left(x+2\right)
Apply the distributive property by multiplying each term of x+8 by each term of 2x+5.
2x^{2}+21x+40-\left(x+8\right)\left(x+2\right)
Combine 5x and 16x to get 21x.
2x^{2}+21x+40-\left(x^{2}+2x+8x+16\right)
Apply the distributive property by multiplying each term of x+8 by each term of x+2.
2x^{2}+21x+40-\left(x^{2}+10x+16\right)
Combine 2x and 8x to get 10x.
2x^{2}+21x+40-x^{2}-10x-16
To find the opposite of x^{2}+10x+16, find the opposite of each term.
x^{2}+21x+40-10x-16
Combine 2x^{2} and -x^{2} to get x^{2}.
x^{2}+11x+40-16
Combine 21x and -10x to get 11x.
x^{2}+11x+24
Subtract 16 from 40 to get 24.
2x^{2}+5x+16x+40-\left(x+8\right)\left(x+2\right)
Apply the distributive property by multiplying each term of x+8 by each term of 2x+5.
2x^{2}+21x+40-\left(x+8\right)\left(x+2\right)
Combine 5x and 16x to get 21x.
2x^{2}+21x+40-\left(x^{2}+2x+8x+16\right)
Apply the distributive property by multiplying each term of x+8 by each term of x+2.
2x^{2}+21x+40-\left(x^{2}+10x+16\right)
Combine 2x and 8x to get 10x.
2x^{2}+21x+40-x^{2}-10x-16
To find the opposite of x^{2}+10x+16, find the opposite of each term.
x^{2}+21x+40-10x-16
Combine 2x^{2} and -x^{2} to get x^{2}.
x^{2}+11x+40-16
Combine 21x and -10x to get 11x.
x^{2}+11x+24
Subtract 16 from 40 to get 24.