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p^{2}-4pq+4q^{2}-\left(2p+q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(p-2q\right)^{2}.
p^{2}-4pq+4q^{2}-\left(4p^{2}+4pq+q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+q\right)^{2}.
p^{2}-4pq+4q^{2}-4p^{2}-4pq-q^{2}
To find the opposite of 4p^{2}+4pq+q^{2}, find the opposite of each term.
-3p^{2}-4pq+4q^{2}-4pq-q^{2}
Combine p^{2} and -4p^{2} to get -3p^{2}.
-3p^{2}-8pq+4q^{2}-q^{2}
Combine -4pq and -4pq to get -8pq.
-3p^{2}-8pq+3q^{2}
Combine 4q^{2} and -q^{2} to get 3q^{2}.
p^{2}-4pq+4q^{2}-\left(2p+q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(p-2q\right)^{2}.
p^{2}-4pq+4q^{2}-\left(4p^{2}+4pq+q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+q\right)^{2}.
p^{2}-4pq+4q^{2}-4p^{2}-4pq-q^{2}
To find the opposite of 4p^{2}+4pq+q^{2}, find the opposite of each term.
-3p^{2}-4pq+4q^{2}-4pq-q^{2}
Combine p^{2} and -4p^{2} to get -3p^{2}.
-3p^{2}-8pq+4q^{2}-q^{2}
Combine -4pq and -4pq to get -8pq.
-3p^{2}-8pq+3q^{2}
Combine 4q^{2} and -q^{2} to get 3q^{2}.