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Differentiate w.r.t. a
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\left(a^{4}\right)^{2}\left(a^{5}\right)^{-2}
Use the rules of exponents to simplify the expression.
a^{4\times 2}a^{5\left(-2\right)}
To raise a power to another power, multiply the exponents.
a^{8}a^{5\left(-2\right)}
Multiply 4 times 2.
a^{8}a^{-10}
Multiply 5 times -2.
a^{8-10}
To multiply powers of the same base, add their exponents.
a^{-2}
Add the exponents 8 and -10.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{8}\left(a^{5}\right)^{-2})
To raise a power to another power, multiply the exponents. Multiply 4 and 2 to get 8.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{8}a^{-10})
To raise a power to another power, multiply the exponents. Multiply 5 and -2 to get -10.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{-2})
To multiply powers of the same base, add their exponents. Add 8 and -10 to get -2.
-2a^{-2-1}
The derivative of ax^{n} is nax^{n-1}.
-2a^{-3}
Subtract 1 from -2.