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Differentiate w.r.t. a
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\left(a^{4}\right)^{-3}\times \frac{1}{\frac{1}{a}}
Use the rules of exponents to simplify the expression.
a^{4\left(-3\right)}a^{-\left(-1\right)}
To raise a power to another power, multiply the exponents.
a^{-12}a^{-\left(-1\right)}
Multiply 4 times -3.
a^{-12}a^{1}
Multiply -1 times -1.
a^{-12+1}
To multiply powers of the same base, add their exponents.
a^{-11}
Add the exponents -12 and 1.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{a^{-12}}{a^{-1}})
To raise a power to another power, multiply the exponents. Multiply 4 and -3 to get -12.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{a^{11}})
Rewrite a^{-1} as a^{-12}a^{11}. Cancel out a^{-12} in both numerator and denominator.
-\left(a^{11}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}a}(a^{11})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(a^{11}\right)^{-2}\times 11a^{11-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-11a^{10}\left(a^{11}\right)^{-2}
Simplify.