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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\left(a^{-\frac{1}{4}}\right)^{\frac{2}{3}})
To multiply powers of the same base, add their exponents. Add -\frac{3}{4} and \frac{1}{2} to get -\frac{1}{4}.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{-\frac{1}{6}})
To raise a power to another power, multiply the exponents. Multiply -\frac{1}{4} and \frac{2}{3} to get -\frac{1}{6}.
-\frac{1}{6}a^{-\frac{1}{6}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{1}{6}a^{-\frac{7}{6}}
Subtract 1 from -\frac{1}{6}.
\left(a^{-\frac{1}{4}}\right)^{\frac{2}{3}}
To multiply powers of the same base, add their exponents. Add -\frac{3}{4} and \frac{1}{2} to get -\frac{1}{4}.