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Evaluate
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Differentiate w.r.t. x
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-9x^{10}z^{2}x^{5}y^{3}
Multiply 9 and -1 to get -9.
-9x^{15}z^{2}y^{3}
To multiply powers of the same base, add their exponents. Add 10 and 5 to get 15.