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Differentiate w.r.t. x
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8x^{2}y^{4}\times \left(\frac{4\times \frac{1}{y}}{x^{3}y^{8}}\right)^{-1}
Cancel out x in both numerator and denominator.
8x^{2}y^{4}\times \left(\frac{4}{x^{3}y^{9}}\right)^{-1}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
8x^{2}y^{4}\times \frac{4^{-1}}{\left(x^{3}y^{9}\right)^{-1}}
To raise \frac{4}{x^{3}y^{9}} to a power, raise both numerator and denominator to the power and then divide.
\frac{8\times 4^{-1}}{\left(x^{3}y^{9}\right)^{-1}}x^{2}y^{4}
Express 8\times \frac{4^{-1}}{\left(x^{3}y^{9}\right)^{-1}} as a single fraction.
\frac{8\times \frac{1}{4}}{\left(x^{3}y^{9}\right)^{-1}}x^{2}y^{4}
Calculate 4 to the power of -1 and get \frac{1}{4}.
\frac{2}{\left(x^{3}y^{9}\right)^{-1}}x^{2}y^{4}
Multiply 8 and \frac{1}{4} to get 2.
\frac{2}{\left(x^{3}\right)^{-1}\left(y^{9}\right)^{-1}}x^{2}y^{4}
Expand \left(x^{3}y^{9}\right)^{-1}.
\frac{2}{x^{-3}\left(y^{9}\right)^{-1}}x^{2}y^{4}
To raise a power to another power, multiply the exponents. Multiply 3 and -1 to get -3.
\frac{2}{x^{-3}y^{-9}}x^{2}y^{4}
To raise a power to another power, multiply the exponents. Multiply 9 and -1 to get -9.
\frac{2x^{2}}{x^{-3}y^{-9}}y^{4}
Express \frac{2}{x^{-3}y^{-9}}x^{2} as a single fraction.
\frac{2x^{5}}{y^{-9}}y^{4}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{2x^{5}y^{4}}{y^{-9}}
Express \frac{2x^{5}}{y^{-9}}y^{4} as a single fraction.
2x^{5}y^{13}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.