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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{8c^{2}b^{3}}{4c^{2}b^{3}}a^{2-4})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(2a^{-2})
Do the arithmetic.
-2\times 2a^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-4a^{-3}
Do the arithmetic.
\frac{2}{a^{2}}
Cancel out 4a^{2}c^{2}b^{3} in both numerator and denominator.