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\frac{8^{\frac{20}{3}}\times 4^{-4}}{16^{2}}
To raise a power to another power, multiply the exponents. Multiply \frac{4}{3} and 5 to get \frac{20}{3}.
\frac{1048576\times 4^{-4}}{16^{2}}
Calculate 8 to the power of \frac{20}{3} and get 1048576.
\frac{1048576\times \frac{1}{256}}{16^{2}}
Calculate 4 to the power of -4 and get \frac{1}{256}.
\frac{4096}{16^{2}}
Multiply 1048576 and \frac{1}{256} to get 4096.
\frac{4096}{256}
Calculate 16 to the power of 2 and get 256.
16
Divide 4096 by 256 to get 16.