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25x^{2}-10xy+y^{2}-\left(y+4x\right)^{2}-9x^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(5x-y\right)^{2}.
25x^{2}-10xy+y^{2}-\left(y^{2}+8yx+16x^{2}\right)-9x^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+4x\right)^{2}.
25x^{2}-10xy+y^{2}-y^{2}-8yx-16x^{2}-9x^{2}
To find the opposite of y^{2}+8yx+16x^{2}, find the opposite of each term.
25x^{2}-10xy-8yx-16x^{2}-9x^{2}
Combine y^{2} and -y^{2} to get 0.
25x^{2}-18xy-16x^{2}-9x^{2}
Combine -10xy and -8yx to get -18xy.
9x^{2}-18xy-9x^{2}
Combine 25x^{2} and -16x^{2} to get 9x^{2}.
-18xy
Combine 9x^{2} and -9x^{2} to get 0.
25x^{2}-10xy+y^{2}-\left(y+4x\right)^{2}-9x^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(5x-y\right)^{2}.
25x^{2}-10xy+y^{2}-\left(y^{2}+8yx+16x^{2}\right)-9x^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+4x\right)^{2}.
25x^{2}-10xy+y^{2}-y^{2}-8yx-16x^{2}-9x^{2}
To find the opposite of y^{2}+8yx+16x^{2}, find the opposite of each term.
25x^{2}-10xy-8yx-16x^{2}-9x^{2}
Combine y^{2} and -y^{2} to get 0.
25x^{2}-18xy-16x^{2}-9x^{2}
Combine -10xy and -8yx to get -18xy.
9x^{2}-18xy-9x^{2}
Combine 25x^{2} and -16x^{2} to get 9x^{2}.
-18xy
Combine 9x^{2} and -9x^{2} to get 0.