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\left(5x^{3}-10x^{2}\right)\left(216x^{3}-5400x^{2}+45000x-125000\right)
Use binomial theorem \left(a-b\right)^{3}=a^{3}-3a^{2}b+3ab^{2}-b^{3} to expand \left(6x-50\right)^{3}.
1080x^{6}-29160x^{5}+279000x^{4}-1075000x^{3}+1250000x^{2}
Use the distributive property to multiply 5x^{3}-10x^{2} by 216x^{3}-5400x^{2}+45000x-125000 and combine like terms.
\left(5x^{3}-10x^{2}\right)\left(216x^{3}-5400x^{2}+45000x-125000\right)
Use binomial theorem \left(a-b\right)^{3}=a^{3}-3a^{2}b+3ab^{2}-b^{3} to expand \left(6x-50\right)^{3}.
1080x^{6}-29160x^{5}+279000x^{4}-1075000x^{3}+1250000x^{2}
Use the distributive property to multiply 5x^{3}-10x^{2} by 216x^{3}-5400x^{2}+45000x-125000 and combine like terms.