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Differentiate w.r.t. x
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\frac{1}{\left(-2x^{-3}y^{5}\right)^{-2}}
Calculate 5x^{2}y^{3} to the power of 0 and get 1.
\frac{1}{\left(-2\right)^{-2}\left(x^{-3}\right)^{-2}\left(y^{5}\right)^{-2}}
Expand \left(-2x^{-3}y^{5}\right)^{-2}.
\frac{1}{\left(-2\right)^{-2}x^{6}\left(y^{5}\right)^{-2}}
To raise a power to another power, multiply the exponents. Multiply -3 and -2 to get 6.
\frac{1}{\left(-2\right)^{-2}x^{6}y^{-10}}
To raise a power to another power, multiply the exponents. Multiply 5 and -2 to get -10.
\frac{1}{\frac{1}{4}x^{6}y^{-10}}
Calculate -2 to the power of -2 and get \frac{1}{4}.