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Differentiate w.r.t. b
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5^{1}b^{8}b^{-12}\left(-10\right)^{1}b^{3}b^{-12}
Use the rules of exponents to simplify the expression.
5^{1}\left(-10\right)^{1}b^{8}b^{3}b^{-12}b^{-12}
Use the Commutative Property of Multiplication.
5^{1}\left(-10\right)^{1}b^{8+3}b^{-12-12}
To multiply powers of the same base, add their exponents.
5^{1}\left(-10\right)^{1}b^{11}b^{-12-12}
Add the exponents 8 and 3.
5^{1}\left(-10\right)^{1}b^{11}b^{-24}
Add the exponents -12 and -12.
-50b^{11}\times \frac{1}{b^{24}}
Multiply 5 times -10.
\frac{\mathrm{d}}{\mathrm{d}b}(5b^{-4}\left(-10\right)b^{3}b^{-12})
To multiply powers of the same base, add their exponents. Add 8 and -12 to get -4.
\frac{\mathrm{d}}{\mathrm{d}b}(5b^{-1}\left(-10\right)b^{-12})
To multiply powers of the same base, add their exponents. Add -4 and 3 to get -1.
\frac{\mathrm{d}}{\mathrm{d}b}(5b^{-13}\left(-10\right))
To multiply powers of the same base, add their exponents. Add -1 and -12 to get -13.
\frac{\mathrm{d}}{\mathrm{d}b}(-50b^{-13})
Multiply 5 and -10 to get -50.
-13\left(-50\right)b^{-13-1}
The derivative of ax^{n} is nax^{n-1}.
650b^{-13-1}
Multiply -13 times -50.
650b^{-14}
Subtract 1 from -13.