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16a^{2}+48ab+36b^{2}-16\left(4a+6b\right)+64
Use binomial theorem \left(p+q\right)^{2}=p^{2}+2pq+q^{2} to expand \left(4a+6b\right)^{2}.
16a^{2}+48ab+36b^{2}-64a-96b+64
Use the distributive property to multiply -16 by 4a+6b.
16a^{2}+48ab+36b^{2}-16\left(4a+6b\right)+64
Use binomial theorem \left(p+q\right)^{2}=p^{2}+2pq+q^{2} to expand \left(4a+6b\right)^{2}.
16a^{2}+48ab+36b^{2}-64a-96b+64
Use the distributive property to multiply -16 by 4a+6b.