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4\left(\left(a^{2}\right)^{2}+18a^{2}+81\right)-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
Use binomial theorem \left(p+q\right)^{2}=p^{2}+2pq+q^{2} to expand \left(a^{2}+9\right)^{2}.
4\left(a^{4}+18a^{2}+81\right)-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
4a^{4}+72a^{2}+324-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
Use the distributive property to multiply 4 by a^{4}+18a^{2}+81.
4a^{4}+72a^{2}+324-\left(-a^{2}+9\right)\left(a^{2}+9\right)
Use the distributive property to multiply a+3 by 3-a and combine like terms.
4a^{4}+72a^{2}+324-\left(-a^{4}+81\right)
Use the distributive property to multiply -a^{2}+9 by a^{2}+9 and combine like terms.
4a^{4}+72a^{2}+324+a^{4}-81
To find the opposite of -a^{4}+81, find the opposite of each term.
5a^{4}+72a^{2}+324-81
Combine 4a^{4} and a^{4} to get 5a^{4}.
5a^{4}+72a^{2}+243
Subtract 81 from 324 to get 243.
4\left(\left(a^{2}\right)^{2}+18a^{2}+81\right)-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
Use binomial theorem \left(p+q\right)^{2}=p^{2}+2pq+q^{2} to expand \left(a^{2}+9\right)^{2}.
4\left(a^{4}+18a^{2}+81\right)-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
4a^{4}+72a^{2}+324-\left(a+3\right)\left(3-a\right)\left(a^{2}+9\right)
Use the distributive property to multiply 4 by a^{4}+18a^{2}+81.
4a^{4}+72a^{2}+324-\left(-a^{2}+9\right)\left(a^{2}+9\right)
Use the distributive property to multiply a+3 by 3-a and combine like terms.
4a^{4}+72a^{2}+324-\left(-a^{4}+81\right)
Use the distributive property to multiply -a^{2}+9 by a^{2}+9 and combine like terms.
4a^{4}+72a^{2}+324+a^{4}-81
To find the opposite of -a^{4}+81, find the opposite of each term.
5a^{4}+72a^{2}+324-81
Combine 4a^{4} and a^{4} to get 5a^{4}.
5a^{4}+72a^{2}+243
Subtract 81 from 324 to get 243.