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\frac{4\left(-2\right)^{2}\left(x^{2}\right)^{2}\left(y^{3}\right)^{2}}{\left(\left(-x\right)y\right)^{3}}
Expand \left(-2x^{2}y^{3}\right)^{2}.
\frac{4\left(-2\right)^{2}x^{4}\left(y^{3}\right)^{2}}{\left(\left(-x\right)y\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
\frac{4\left(-2\right)^{2}x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
\frac{4\times 4x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
Calculate -2 to the power of 2 and get 4.
\frac{16x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
Multiply 4 and 4 to get 16.
\frac{16x^{4}y^{6}}{\left(-x\right)^{3}y^{3}}
Expand \left(\left(-x\right)y\right)^{3}.
\frac{16y^{3}x^{4}}{\left(-x\right)^{3}}
Cancel out y^{3} in both numerator and denominator.
\frac{16y^{3}x^{4}}{\left(-1\right)^{3}x^{3}}
Expand \left(-x\right)^{3}.
\frac{16y^{3}x^{4}}{-x^{3}}
Calculate -1 to the power of 3 and get -1.
\frac{16xy^{3}}{-1}
Cancel out x^{3} in both numerator and denominator.
-16xy^{3}
Anything divided by -1 gives its opposite.
\frac{4\left(-2\right)^{2}\left(x^{2}\right)^{2}\left(y^{3}\right)^{2}}{\left(\left(-x\right)y\right)^{3}}
Expand \left(-2x^{2}y^{3}\right)^{2}.
\frac{4\left(-2\right)^{2}x^{4}\left(y^{3}\right)^{2}}{\left(\left(-x\right)y\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
\frac{4\left(-2\right)^{2}x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
\frac{4\times 4x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
Calculate -2 to the power of 2 and get 4.
\frac{16x^{4}y^{6}}{\left(\left(-x\right)y\right)^{3}}
Multiply 4 and 4 to get 16.
\frac{16x^{4}y^{6}}{\left(-x\right)^{3}y^{3}}
Expand \left(\left(-x\right)y\right)^{3}.
\frac{16y^{3}x^{4}}{\left(-x\right)^{3}}
Cancel out y^{3} in both numerator and denominator.
\frac{16y^{3}x^{4}}{\left(-1\right)^{3}x^{3}}
Expand \left(-x\right)^{3}.
\frac{16y^{3}x^{4}}{-x^{3}}
Calculate -1 to the power of 3 and get -1.
\frac{16xy^{3}}{-1}
Cancel out x^{3} in both numerator and denominator.
-16xy^{3}
Anything divided by -1 gives its opposite.