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Differentiate w.r.t. x
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27^{\frac{5}{3}}\left(x^{6}\right)^{\frac{5}{3}}
Expand \left(27x^{6}\right)^{\frac{5}{3}}.
27^{\frac{5}{3}}x^{10}
To raise a power to another power, multiply the exponents. Multiply 6 and \frac{5}{3} to get 10.
243x^{10}
Calculate 27 to the power of \frac{5}{3} and get 243.
\frac{5}{3}\times \left(27x^{6}\right)^{\frac{5}{3}-1}\frac{\mathrm{d}}{\mathrm{d}x}(27x^{6})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
\frac{5}{3}\times \left(27x^{6}\right)^{\frac{2}{3}}\times 6\times 27x^{6-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
270x^{5}\times \left(27x^{6}\right)^{\frac{2}{3}}
Simplify.