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Differentiate w.r.t. x
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216^{-\frac{4}{3}}\left(x^{-2}\right)^{-\frac{4}{3}}
Expand \left(216x^{-2}\right)^{-\frac{4}{3}}.
216^{-\frac{4}{3}}x^{\frac{8}{3}}
To raise a power to another power, multiply the exponents. Multiply -2 and -\frac{4}{3} to get \frac{8}{3}.
\frac{1}{1296}x^{\frac{8}{3}}
Calculate 216 to the power of -\frac{4}{3} and get \frac{1}{1296}.
-\frac{4}{3}\times \left(216x^{-2}\right)^{-\frac{4}{3}-1}\frac{\mathrm{d}}{\mathrm{d}x}(216x^{-2})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\frac{4}{3}\times \left(216x^{-2}\right)^{-\frac{7}{3}}\left(-2\right)\times 216x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
576x^{-3}\times \left(216x^{-2}\right)^{-\frac{7}{3}}
Simplify.