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16x^{2}-4xy+2x-40yx+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Apply the distributive property by multiplying each term of 2x-5y-4 by each term of 8x-2y+1.
16x^{2}-44xy+2x+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine -4xy and -40yx to get -44xy.
16x^{2}-44xy-30x+10y^{2}-5y+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine 2x and -32x to get -30x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine -5y and 8y to get 3y.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4-8x+8x+16x^{2}\right)-10\left(-4\right)x
Apply the distributive property by multiplying each term of 2-4x by each term of -2-4x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4+16x^{2}\right)-10\left(-4\right)x
Combine -8x and 8x to get 0.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4\right)-16x^{2}-10\left(-4\right)x
To find the opposite of -4+16x^{2}, find the opposite of each term.
16x^{2}-44xy-30x+10y^{2}+3y-4+4-16x^{2}-10\left(-4\right)x
The opposite of -4 is 4.
16x^{2}-44xy-30x+10y^{2}+3y-16x^{2}-10\left(-4\right)x
Add -4 and 4 to get 0.
-44xy-30x+10y^{2}+3y-10\left(-4\right)x
Combine 16x^{2} and -16x^{2} to get 0.
-44xy-30x+10y^{2}+3y-\left(-40x\right)
Multiply 10 and -4 to get -40.
-44xy-30x+10y^{2}+3y+40x
The opposite of -40x is 40x.
-44xy+10x+10y^{2}+3y
Combine -30x and 40x to get 10x.
16x^{2}-4xy+2x-40yx+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Apply the distributive property by multiplying each term of 2x-5y-4 by each term of 8x-2y+1.
16x^{2}-44xy+2x+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine -4xy and -40yx to get -44xy.
16x^{2}-44xy-30x+10y^{2}-5y+8y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine 2x and -32x to get -30x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(2-4x\right)\left(-2-4x\right)-10\left(-4\right)x
Combine -5y and 8y to get 3y.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4-8x+8x+16x^{2}\right)-10\left(-4\right)x
Apply the distributive property by multiplying each term of 2-4x by each term of -2-4x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4+16x^{2}\right)-10\left(-4\right)x
Combine -8x and 8x to get 0.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4\right)-16x^{2}-10\left(-4\right)x
To find the opposite of -4+16x^{2}, find the opposite of each term.
16x^{2}-44xy-30x+10y^{2}+3y-4+4-16x^{2}-10\left(-4\right)x
The opposite of -4 is 4.
16x^{2}-44xy-30x+10y^{2}+3y-16x^{2}-10\left(-4\right)x
Add -4 and 4 to get 0.
-44xy-30x+10y^{2}+3y-10\left(-4\right)x
Combine 16x^{2} and -16x^{2} to get 0.
-44xy-30x+10y^{2}+3y-\left(-40x\right)
Multiply 10 and -4 to get -40.
-44xy-30x+10y^{2}+3y+40x
The opposite of -40x is 40x.
-44xy+10x+10y^{2}+3y
Combine -30x and 40x to get 10x.