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16x^{2}-4xy+2x-40yx+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Apply the distributive property by multiplying each term of 2x-5y-4 by each term of 8x-2y+1.
16x^{2}-44xy+2x+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine -4xy and -40yx to get -44xy.
16x^{2}-44xy-30x+10y^{2}-5y+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine 2x and -32x to get -30x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine -5y and 8y to get 3y.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4-8x+8x+16x^{2}\right)-10
Apply the distributive property by multiplying each term of 2-4x by each term of -2-4x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4+16x^{2}\right)-10
Combine -8x and 8x to get 0.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4\right)-16x^{2}-10
To find the opposite of -4+16x^{2}, find the opposite of each term.
16x^{2}-44xy-30x+10y^{2}+3y-4+4-16x^{2}-10
The opposite of -4 is 4.
16x^{2}-44xy-30x+10y^{2}+3y-16x^{2}-10
Add -4 and 4 to get 0.
-44xy-30x+10y^{2}+3y-10
Combine 16x^{2} and -16x^{2} to get 0.
16x^{2}-4xy+2x-40yx+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Apply the distributive property by multiplying each term of 2x-5y-4 by each term of 8x-2y+1.
16x^{2}-44xy+2x+10y^{2}-5y-32x+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine -4xy and -40yx to get -44xy.
16x^{2}-44xy-30x+10y^{2}-5y+8y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine 2x and -32x to get -30x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(2-4x\right)\left(-2-4x\right)-10
Combine -5y and 8y to get 3y.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4-8x+8x+16x^{2}\right)-10
Apply the distributive property by multiplying each term of 2-4x by each term of -2-4x.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4+16x^{2}\right)-10
Combine -8x and 8x to get 0.
16x^{2}-44xy-30x+10y^{2}+3y-4-\left(-4\right)-16x^{2}-10
To find the opposite of -4+16x^{2}, find the opposite of each term.
16x^{2}-44xy-30x+10y^{2}+3y-4+4-16x^{2}-10
The opposite of -4 is 4.
16x^{2}-44xy-30x+10y^{2}+3y-16x^{2}-10
Add -4 and 4 to get 0.
-44xy-30x+10y^{2}+3y-10
Combine 16x^{2} and -16x^{2} to get 0.